Hungry Gel: An Artificial Macrophage Based on a DNA Hydrogel
Abstract
Inspired by the phagocytic function of macrophages,
we have designed an intelligent DNA hydrogel
that autonomously recognizes and engulfs target bacteria.
This system integrates three functional DNA modules: a DNA aptamer as a sensor,
an entropy-driven circuit as a signal amplifier, and the DNA hydrogel itself
as the capturing medium. The process is initiated
when the aptamer specifically binds to a target bacterium.
This recognition event triggers the amplification circuit,
causing a massive release of single-stranded DNA that
cleaves the hydrogel's cross-links. Consequently, the hydrogel matrix selectively
dissolves in the immediate proximity of the bacterium, thereby
capturing and enclosing it in a manner analogous to cellular phagocytosis.
We will experimentally demonstrate these core functions.
Looking ahead, this platform holds promise for future applications
as an "artificial macrophage" by incorporating a bactericidal or neutralizing
function, offering a novel therapeutic strategy for bacterial infections.
YouTube
Hi! We are Team Sendai. Please watch our project introduction video on YouTube to learn more about "Hungry Gel," our artificial macrophage.